Ethyl cyclohexanoate → 3,7-dihydro-3-methyl-7-([5-cyclohexyl-1,2,4-oxadiazole-3-yl]methyl)-1H-purine-2,6-dione

HRID 1904905Notes

Reaction equation

HRID 1904905 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:11][C:12](=[N:14][OH:15])[NH2:13])[C:6]=2[C:5](=[O:16])[NH:4][C:3]1=[O:17].[Na].[CH:19]1([C:25](OCC)=O)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(O)C>[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:11][C:12]3[N:13]=[C:25]([CH:19]4[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]4)[O:15][N:14]=3)[C:6]=2[C:5](=[O:16])[NH:4][C:3]1=[O:17]

Participants

5

Reactant 3

HCID 18686Ethyl cyclohexanoateHCID 5360545SodiumHCID 537117962-(3-Methyl-xanthine-7-yl)acetamidoxime

Product 1

HCID 147484583,7-dihydro-3-methyl-7-([5-cyclohexyl-1,2,4-oxadiazole-3-yl]methyl)-1H-purine-2,6-dioneYield 76%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 2.38 g of 2-(3-methyl-xanthine-7-yl)acetamidoxime in 25 ml of ethanol is admixed with a solution of 0.46 g of metallic sodium in 25 ml of ethanol and 3.02 g of ethyl cyclohexane carboxylate. The reaction mixture is heated to boiling under stirring for 10 hours, then evaporated. The residue is admixed with water and the pH is adjusted to 7. The precipitate is crystallized from aqueous ethanol. Thus 2.51 g of 3,7-dihydro-3-methyl-7-([5-cyclohexyl-1,2,4-oxadiazole-3-yl]methyl)-1H-purine-2,6-dione are obtained, m.p.: 245°-248° C.

Workup

  1. temperatureThe reaction mixture is heated
  2. customevaporated
  3. customThe precipitate is crystallized from aqueous ethanol

Sources & evidence

ORD record
ord-21fc83428b274d28a216df1e6e05e9c6
Source dataset
uspto-grants-1989_06
Patent number
US04840949

Reaction notes

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