反应详情

To a solution of 200 mg (1.2 mmol) of 4-amino-1,1-dimethylindane and 0.15 g (1.9 mmol) of pyridine in 15 ml of ethyl acetate was added 0.24 g (1.4 mmol) of 2-chloronicotinic acid chloride under ice cooling, and the mixture was stirred at room temperature for one hour. The reaction mixture was poured into ice water and extracted with ethyl acetate. The extract was washed with water, dried over Glauber's salt and then concentrated under reduced pressure. The white residue was recrystallized with hexane to obtain 300 mg of white crystals (Compound No. 1 shown in Table 2). The yield was 80.4%.

1. extractionextracted with ethyl acetate
2. washThe extract was washed with water
3. dry with materialdried over Glauber's salt
4. concentrationconcentrated under reduced pressure
5. customThe white residue was recrystallized with hexane