4-Methylphenyl isocyanate → 3-ethoxycarbonyl-9-(4-methylphenylcarbamoylthio)-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 1904935Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1904935
[CH2:1]([O:3][C:4]([C:6]1[C:11](=[O:12])[N:10]2[CH:13]=[CH:14][CH:15]=[C:16]([SH:17])[C:9]2=[N:8][CH:7]=1)=[O:5])[CH3:2].[CH3:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]=[C:26]=[O:27])=[CH:21][CH:20]=1>C(Cl)Cl>[CH2:1]([O:3][C:4]([C:6]1[C:11](=[O:12])[N:10]2[CH:13]=[CH:14][CH:15]=[C:16]([S:17][C:26](=[O:27])[NH:25][C:22]3[CH:23]=[CH:24][C:19]([CH3:18])=[CH:20][CH:21]=3)[C:9]2=[N:8][CH:7]=1)=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 693254-Methylphenyl isocyanateHCID 143064713-ethoxycarbonyl-9-mercapto-4H-pyrido[1,2-a]pyrimidin-4-one

Produkt 1

HCID 143063953-ethoxycarbonyl-9-(4-methylphenylcarbamoylthio)-4H-pyrido[1,2-a]pyrimidin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a suspension of 0.4 g of 3-ethoxycarbonyl-9-mercapto-4H-pyrido[1,2-a]pyrimidin-4-one II-1 in 10 ml of dry CH2Cl2 is added 0.35 g of 4-methylphenyl isocyanate III-1, and the resultant mixture is stirred at room temperature for 4 hours. At this time the reaction mixture is crystallized again after it is once dissolved.

Aufarbeitung

  1. customAt this time the reaction mixture is crystallized again after it
  2. dissolutionis once dissolved

Quellen und Nachweise

ORD-Eintrag
ord-4de4c8e5f401416d8f77e6bee5ed4658
Quelldatensatz
uspto-grants-1989_06
Patentnummer
US04840953

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