反应详情

Under a nitrogen atmosphere, 10 ml of 70% perchloric acid was added to a solution of 6.1 g of 2-(4-trifluoromethylphenyl)-3,3,3-trifluoropropenyl methyl ether in 20 ml of diethyl ether at 0° to 5° C. The reaction solution was stirred at room temperature for 14 hours. The reaction mixture was poured into ice water and extracted twice with diethyl ether. The ether layers were combined and washed with saturated sodium bisulfate solution and saturated sodium chloride solution successively and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to obtain 2.1 g of the desired crude compound.

1. extractionextracted twice with diethyl ether
2. washwashed with saturated sodium bisulfate solution and saturated sodium chloride solution successively
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was removed under reduced pressure