Acetoacetic Acid → Methyl acetoacetate

HRID 1905021Notes

Reaction equation

HRID 1905021 reaction equation
[C:1]([OH:7])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[NH3:8].[CH3:9][Si:10]([CH3:19])([CH3:18])[C:11]1[O:17][C:14]([CH2:15][OH:16])=[CH:13][CH:12]=1>CO>[C:1]([O:7][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[NH2:8]/[C:3](/[CH3:5])=[CH:2]\[C:1]([OH:7])=[O:6].[CH3:9][Si:10]([CH3:19])([CH3:18])[C:11]1[O:17][C:14]([CH2:15][OH:16])=[CH:13][CH:12]=1

Participants

7

Reactant 3

HCID 96Acetoacetic AcidHCID 222AmmoniaHCID 13815269[5-(Trimethylsilyl)furan-2-yl]methanol

Product 3

HCID 7757Methyl acetoacetateHCID 13815269[5-(Trimethylsilyl)furan-2-yl]methanolHCID 19107567HCID 19107567, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound is prepared by the method comprising condensation of methyl ester of acetoacetic acid, ammonia and 5-trimethylsilylfurfurol in solution of methanol. Furthermore, this compound can be obtained by condensation of methyl ester of acetoacetic acid, methyl ester of β-aminocrotonic acid and 5-trimethylsilylfurfurol in a medium of an organic solvent. The reaction is carried out under normal pressure under heating. The product is obtained in a good yield.

Workup

  1. customThis compound is prepared by the method

Sources & evidence

ORD record
ord-fc26e80a84284b798879fe42c9bb6429
Source dataset
uspto-grants-1989_06
Patent number
US04841054

Reaction notes

Loading…