HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetoacetic Acid → Methyl acetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetoacetic Acid | HCID 96 | — |
| Reactant | Ammonia | HCID 222 | — |
| Reactant | [5-(Trimethylsilyl)furan-2-yl]methanol | HCID 13815269 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl acetoacetate | HCID 7757 | — |
| Product | [5-(Trimethylsilyl)furan-2-yl]methanol | HCID 13815269 | — |
| Product | HCID 19107567 | HCID 19107567 | — |
Reaction Steps
This compound is prepared by the method comprising condensation of methyl ester of acetoacetic acid, ammonia and 5-trimethylsilylfurfurol in solution of methanol. Furthermore, this compound can be obtained by condensation of methyl ester of acetoacetic acid, methyl ester of β-aminocrotonic acid and 5-trimethylsilylfurfurol in a medium of an organic solvent. The reaction is carried out under normal pressure under heating. The product is obtained in a good yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04841054 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-fc26e80a84284b798879fe42c9bb6429 |
| Source note | uspto-grants-1989_06 |