反应详情

In 1 l of acetone was suspended 114 g of 5-chloro-7-hydroxy-3-(2-methylphenyl)-4-oxo-4H-1-benzopyran, and 60.4 g of anhydrous potassium carbonate and 73.0 g of ethyl bromoacetate were added thereto, followed by refluxing for 1.5 hours. After cooling, the insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure. Recrystallization of the residue from ethanol gave 132 g of the entitled compound having a melting point of 122° to 123° C.

1. additionwere added
2. temperatureby refluxing for 1.5 hours
3. temperatureAfter cooling
4. customthe insoluble material was removed by filtration
5. concentrationthe filtrate was concentrated under reduced pressure
6. customRecrystallization of the residue from ethanol