HCID 14254522, compound → HCID 14254548, compound

HRID 1905087Notes

Reaction equation

HRID 1905087 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:18])[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:10][O:11][C:6]=2[CH:5]=[C:4]([O:19][CH2:20][C:21]([OH:23])=[O:22])[CH:3]=1>CO.[Pt](=O)=O>[Cl:1][C:2]1[C:7]2[C:8](=[O:18])[CH:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:10][O:11][C:6]=2[CH:5]=[C:4]([O:19][CH2:20][C:21]([OH:23])=[O:22])[CH:3]=1

Participants

4

Reactant 1

HCID 14254522HCID 14254522, compound

Product 1

HCID 14254548HCID 14254548, compoundYield 39.8%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

One gram of {[5-chloro-4-oxo-3-phenyl-4H-1-benzopyran-7-yl]oxy}acetic acid was dissolved in 200 ml of methanol while heating, and 50 mg of platinum (IV) oxide was added to the solution. After an equimole of hydrogen was absorbed, the platinum catalyst was removed by filtration. The methanol in the filtrate was removed by distillation, and the residue was recrystallized from chloroform to obtain 0.4 g of the entitled compound having a melting point of 171° to 173° C.

Workup

  1. temperaturewhile heating
  2. customAfter an equimole of hydrogen was absorbed
  3. customthe platinum catalyst was removed by filtration
  4. customThe methanol in the filtrate was removed by distillation
  5. customthe residue was recrystallized from chloroform

Sources & evidence

ORD record
ord-36427cd6a350409fbf16a397e0b02c05
Source dataset
uspto-grants-1989_06
Patent number
US04841076

Reaction notes

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