Potassium Iodide → HCID 14254547, compound

HRID 1905088Notes

Reaction equation

HRID 1905088 reaction equation
[Cl:1][C:2]1[C:7]2[C:8](=[O:19])[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])=[CH:10][O:11][C:6]=2[CH:5]=[C:4]([OH:20])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:28][C:29]#[N:30].[I-].[K+]>CC(C)=O.O>[Cl:1][C:2]1[C:7]2[C:8](=[O:19])[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[Cl:18])=[CH:10][O:11][C:6]=2[CH:5]=[C:4]([O:20][CH2:28][C:29]#[N:30])[CH:3]=1

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 14254498HCID 14254498, compound

Product 1

HCID 14254547HCID 14254547, compoundYield 88.7%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

In 50 ml of acetone was dissolved 1.4 g of 5-chloro-3-(2-chlorophenyl)-7-hydroxy-4-oxo-4H-1-benzopyran, and 0.7 g of anhydrous potassium carbonate, 0.38 g of chloroacetonitrile and 0.15 g of potassium iodide were added to the solution, followed by refluxing for 8 hours. Water was added to the reaction mixture, and the precipitated crystals were collected by filtration. Recrystallization of the crystals from ethanol gave 1.4 g of the entitled compound having a melting point of 174° to 175° C.

Workup

  1. additionwere added to the solution
  2. temperatureby refluxing for 8 hours
  3. filtrationthe precipitated crystals were collected by filtration
  4. customRecrystallization of the crystals from ethanol

Sources & evidence

ORD record
ord-33f393f989904cbcaf6624c249980a1a
Source dataset
uspto-grants-1989_06
Patent number
US04841076

Reaction notes

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