HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-(2-Formamidothiazol-4-yl)-2-propoxyiminoacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-(2-Amino-4-thiazolyl)-2-propoxyiminoacetic acid | HCID 54096040 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 2-(2-Formamidothiazol-4-yl)-2-propoxyiminoacetic acid | HCID 53687667 | 78.5% |
Reaction Steps
N.M.R. δppm (DMSO-d6): 0.89 (3H, t, J=7 Hz), 1.63 (2H, sextet, J=7 Hz), 4.05 (2H, t, J=7 Hz), 6.83 (1H, s), 6.9-8.8 (3H, broad). (5) 2-(2-Aminothiazol-4-yl)-2-n-propoxyiminoacetic acid (syn isomer, 21.8 g.), acetic anhydride (38.8 g.) and formic acid (17.5 g.) were treated in a similar manner to that of Example F-(5), and then the obtained oil was triturated with diisopropyl ether to give 2-(2-formamidothiazol-4-yl)-2-n-propoxyiminoacetic acid (syn isomer, 19.2 g.), mp. 164° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04841062 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-e9d12495a79e41aa8c3c22e3575f7c03 |
| Source note | uspto-grants-1989_06 |