Hydrochloric Acid → methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride

HRID 1905318Notes

Reaction equation

HRID 1905318 reaction equation
[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([OH:7])=[O:6].[CH3:13]O>>[ClH:1].[NH2:2][C@@H:3]([CH2:9][CH:10]([CH3:12])[CH3:11])[CH:4]([OH:8])[C:5]([O:7][CH3:13])=[O:6]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 12879199(2RS,3S)-3-amino-2-hydroxy-5-methylhexanoic acid

Product 1

HCID 13746619methyl (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride

Procedure

Hydrogen chloride was passed into a solution of 110 mg of (2RS, 3S)-3-amino-2-hydroxy-5-methylhexanoic acid in 10 ml of methanol under ice-cooling, and the mixture was stirred overnight. The reaction mixture was evaporated under reduced pressure to obtained 150 mg of methyl (2RS, 3S)-3-amino-2-hydroxy-5-methyl-hexanoate hydrochloride as a white powder [IR (KBr): νco 1740 cm-1 ].

Workup

  1. temperaturecooling
  2. customThe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-5c76d788742d4814a49a4a7e7a3fa55b
Source dataset
uspto-grants-1989_06
Patent number
US04841067

Reaction notes

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