Water → HCID 14723177, compound

HRID 1905342Notes

Reaction equation

HRID 1905342 reaction equation
CC(C)([O-])C.[K+].[CH2:7]([SH:10])[CH2:8][CH3:9].[CH2:11]([N:16]1[CH2:20][C:19]2[CH:21]=[CH:22][CH:23]=[C:24](Cl)[C:18]=2[S:17]1(=[O:27])=[O:26])[CH2:12][CH2:13][CH2:14][CH3:15].O>CN(C)C=O>[CH2:11]([N:16]1[CH2:20][C:19]2[CH:21]=[CH:22][CH:23]=[C:24]([S:10][CH2:7][CH2:8][CH3:9])[C:18]=2[S:17]1(=[O:27])=[O:26])[CH2:12][CH2:13][CH2:14][CH3:15]

Participants

6

Reactant 4

HCID 962WaterHCID 7848Propyl mercaptanHCID 14723176HCID 14723176, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 14723177HCID 14723177, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 5.0 g of potassium-t-butoxide in 40 ml of dry dimethylformamide was added 4.0 ml of propyl mercaptan at -5° to 0° C. under an inert atmosphere followed by 11.0 g of 2-pentyl-7-chloro-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide. The mixture was stirred at room temperature for 16 hours, poured into water and extracted with n-butyl chloride. The extract was washed with water and brine, dried over MgSO4 and concentrated to give 10.3 g of the title compound as a yellow oil.

Workup

  1. extractionextracted with n-butyl chloride
  2. washThe extract was washed with water and brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-23519dccc58b4293ae8036f85736987c
Source dataset
uspto-grants-1989_06
Patent number
US04842639

Reaction notes

Loading…