Lawesson's reagent → HCID 23036992, compound

HRID 1905344Notes

Reaction equation

HRID 1905344 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[C:13](=O)[NH:12][CH2:11]2)(=[O:5])=[O:4].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:25])=CC=1>C1(C)C(C)=CC=CC=1>[CH3:1][NH:2][S:3]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[C:13](=[S:25])[NH:12][CH2:11]2)(=[O:5])=[O:4]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 23036994HCID 23036994, compound

Product 1

HCID 23036992HCID 23036992, compoundYield 84.8%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 0.68 g of N-methylisoindolin-1-one-7-sulfonamide, 0.61 g of Lawesson's reagent (2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide) and 15 ml of xylene was heated to reflux under nitrogen for 24 hours. The mixture was allowed to cool, the solid products collected, and recrystallized from isopropanol (carbon) to give 0.31 g of the title compound as a yellow solid, m.p. 231°-232° C.

Workup

  1. temperaturewas heated
  2. temperatureto reflux under nitrogen for 24 hours
  3. temperatureto cool
  4. customthe solid products collected
  5. customrecrystallized from isopropanol (carbon)

Sources & evidence

ORD record
ord-c677e43bee9f44899cbfeb97a96669c1
Source dataset
uspto-grants-1989_06
Patent number
US04842639

Reaction notes

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