Ici 109,081 → 6-[4-(2-benzyloxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

HRID 1905417Notes

Reaction equation

HRID 1905417 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[CH2:16]([O:23][C:24]([NH:26][C:27]([CH3:31])([CH3:30])[CH:28]=O)=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([O:23][C:24]([NH:26][C:27]([CH3:31])([CH3:30])[CH2:28][NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1)=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 161928Ici 109,081HCID 14578675(1,1-Dimethyl-2-oxoethyl)carbamic acid benzyl ester

Product 1

HCID 145786766-[4-(2-benzyloxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

Procedure

By treating 6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and 2-(benzyloxycarbonylamino)-2-methylpropanal obtained in 2-a above in the same way as in Example 1, (1-c), 6-[4-(2-benzyloxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone was obtained.

Sources & evidence

ORD record
ord-83ed1954932b47e388eac41d4c841070
Source dataset
uspto-grants-1989_06
Patent number
US04843072

Reaction notes

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