HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → gamma-[4-(2-Methyl-2-nitropropylamino)benzoyl]butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Methyl-2-nitro-1-propanol | HCID 6442 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | gamma-(p-Aminobenzoyl)butyric acid hydrochloride | HCID 67899846 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | Water | HCID 962 | — |
| Product | gamma-[4-(2-Methyl-2-nitropropylamino)benzoyl]butyric acid | HCID 14578679 | 82.4% |
Reaction Steps
A mixture of γ-(p-aminobenzoyl)butyric acid hydrochloride (349.5 g), 2-methyl-2-nitro-1-propanol (222 g), sodium hydroxide (114.8 g), benzyltriethyl ammonium chloride (6.35 g) and water (1.5 liters) was refluxed for 40 hours. Concentrated hydrochloric acid (170 ml) was added to the reaction mixture to acidify it. The precipitated crystals were collected by filtration to give γ-[4-(2-methyl-2-nitropropylamino)benzoyl]butyric acid (364.46 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04843072 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-bca71cbd5a38482dac3260419ad484bd |
| Source note | uspto-grants-1989_06 |