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HRID1905419

反应详情

EQUATION

反应方程式

HRID 1905419 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(CO)[N+](=O)[O-]
HCID6442

2-Methyl-2-nitro-1-propanol

C4H9NO3

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：Cl.Nc1ccc(C(=O)CCCC(=O)O)cc1
HCID67899846

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(CNc1ccc(C(=O)CCCC(=O)O)cc1)[N+](=O)[O-]
HCID14578679

未命名化合物

收率 82.4%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC[N+](CC)(CC)Cc1ccccc1.[Cl-]
催化剂HCID66133

未命名化合物

结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A mixture of γ-(p-aminobenzoyl)butyric acid hydrochloride (349.5 g), 2-methyl-2-nitro-1-propanol (222 g), sodium hydroxide (114.8 g), benzyltriethyl ammonium chloride (6.35 g) and water (1.5 liters) was refluxed for 40 hours. Concentrated hydrochloric acid (170 ml) was added to the reaction mixture to acidify it. The precipitated crystals were collected by filtration to give γ-[4-(2-methyl-2-nitropropylamino)benzoyl]butyric acid (364.46 g).

WORKUP

后处理

  1. temperaturewas refluxed for 40 hours
  2. filtrationThe precipitated crystals were collected by filtration