HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 6-[4-(2-t-butoxycarbonylaminopropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Propanal | HCID 527 | — |
| Reactant | Ici 109,081 | HCID 161928 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 6-[4-(2-benzyloxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone | HCID 14578676 | — |
| Product | 6-[4-(2-t-butoxycarbonylaminopropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone | HCID 14578712 | — |
Reaction Steps
The same operation as in Example 1, (1-c) was carried out by using 6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (2.03 g), 2-butoxycarbonylamino)propanal (2.09 g), acetic acid (0.6 g) and sodium cyanoborohydride (0.33 g), to obtain 6-[4-(2-t-butoxycarbonylaminopropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (2.89 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04843072 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-15d44fa856f8405fbe9f5b407896fa02 |
| Source note | uspto-grants-1989_06 |