Hydrogen Peroxide → N-((2,5-Dichloro-4-(1,1,2,2-tetrafluoroethylsulfinyl)phenyl)carbamoyl)-2,6-difluorobenzamide

Participants

Reaction Conditions

Reaction Steps

In 20 ml of acetic acid was dissolved under heating 0.4 g of N-(2,6-difluorobenzoyl)-N'-[2,5-dichloro-4-(1,1,2,2-tetrafluoroethylthio)phenyl]urea, and 1 ml of 30% hydrogen peroxide aqueous solution was added to the solution, followed by heating at 90° C. for 3.5 hours. The reaction mixture was diluted with water, and the crystals which separated out were recovered by filtration, and washed with water and ethanol successively to give 0.4 g of N-(2,6-difluorobenzoyl)-N'-[2,5-dichloro-4-(1,1,2,2-tetrafluoroethylsulfinyl)phenyl]urea (Compound No. 34), m.p. of 216°-220° C.

Provenance & Evidence