Hydrogen Peroxide → 100341-45-5

HRID 1905450Notes

Reaction equation

HRID 1905450 reaction equation
[F:1][C:2]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:3]=1[C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([S:17][C:18]([F:23])([F:22])[CH:19]([F:21])[F:20])=[CH:12][C:11]=1[Cl:24])=[O:8])=[O:5].[OH:30]O>C(O)(=O)C.O>[F:1][C:2]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:3]=1[C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([S:17]([C:18]([F:22])([F:23])[CH:19]([F:21])[F:20])=[O:30])=[CH:12][C:11]=1[Cl:24])=[O:8])=[O:5]

Participants

5

Reactant 2

HCID 784Hydrogen PeroxideHCID 180798N-((2,5-Dichloro-4-(1,1,2,2-tetrafluoroethylsulfanyl)phenyl)carbamoyl)-2,6-difluorobenzamide

Product 1

HCID 180845100341-45-5

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

In 20 ml of acetic acid was dissolved under heating 0.4 g of N-(2,6-difluorobenzoyl)-N'-[2,5-dichloro-4-(1,1,2,2-tetrafluoroethylthio)phenyl]urea, and 1 ml of 30% hydrogen peroxide aqueous solution was added to the solution, followed by heating at 90° C. for 3.5 hours. The reaction mixture was diluted with water, and the crystals which separated out were recovered by filtration, and washed with water and ethanol successively to give 0.4 g of N-(2,6-difluorobenzoyl)-N'-[2,5-dichloro-4-(1,1,2,2-tetrafluoroethylsulfinyl)phenyl]urea (Compound No. 34), m.p. of 216°-220° C.

Workup

  1. additionwas added to the solution
  2. customthe crystals which separated out
  3. filtrationwere recovered by filtration
  4. washwashed with water and ethanol successively

Sources & evidence

ORD record
ord-92ce9207181d440488074514f2df3c56
Source dataset
uspto-grants-1989_06
Patent number
US04843100

Reaction notes

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