HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → 4-[5-(3-Methyl-5-isoxazolyl)pentyloxy]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-(5-Bromopentyl)-3-methylisoxazole | HCID 13544046 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[5-(3-Methyl-5-isoxazolyl)pentyloxy]benzaldehyde | HCID 6483425 | 67% |
Reaction Steps
A solution of 7.2 g of 4-hydroxybenzaldehyde, 14.6 g of 5-(5-bromopentyl)-3-methylisoxazole, 4 g of potassium hydroxide in 100 ml of acetonitrile was heated at reflux for 1.5 hours. The reaction mixture was cooled and filtered, the solvent removed, and the residue recrystallized from isopropyl acetate-hexane to give 10.8 g of 4-[5-(3-methyl-5-isoxazolyl)pentyloxy]benzaldehyde as a pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04843087 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-8b10ff1da1104a44b9eaf87787e80a76 |
| Source note | uspto-grants-1989_06 |