反应详情

A solution of 7.2 g of 4-hydroxybenzaldehyde, 14.6 g of 5-(5-bromopentyl)-3-methylisoxazole, 4 g of potassium hydroxide in 100 ml of acetonitrile was heated at reflux for 1.5 hours. The reaction mixture was cooled and filtered, the solvent removed, and the residue recrystallized from isopropyl acetate-hexane to give 10.8 g of 4-[5-(3-methyl-5-isoxazolyl)pentyloxy]benzaldehyde as a pale yellow powder.

1. temperatureat reflux for 1.5 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. customthe solvent removed
5. customthe residue recrystallized from isopropyl acetate-hexane