Ammonia → 4-(2-Aminopropan-2-yl)phenol

HRID 1905549Notes

Reaction equation

HRID 1905549 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)=[CH2:3].[NH3:11]>>[NH2:11][C:2]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([CH3:1])[CH3:3]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 584247p-Isopropenylphenol

Product 1

HCID 141781264-(2-Aminopropan-2-yl)phenol

Procedure

A 0.10-g sample of 4-(1-methylethenyl)phenol is exposed to excess, gaseous ammonia for about one day at 50° C. After excess ammonia is purged, a quantitative yield of 2-amino-2-(4-hydroxyphenyl)propane is obtained. No 1-amino-2-(4-hydroxyphenyl)propane is detectable by 60 MHz proton NMR.

Workup

  1. customfor about one day
  2. customat 50° C
  3. customAfter excess ammonia is purged

Sources & evidence

ORD record
ord-e169062d2a044d4e89161f26aad11c43
Source dataset
uspto-grants-1989_06
Patent number
US04843160

Reaction notes

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