Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 13474746 | HCID 13474746 | — |
| Product | HCID 13730839 | HCID 13730839 | — |
Reaction Steps
A solution of 6-difluoromethoxy-2-[(1-carbamoyl-1,2-dimethylpropyl)-carbamoyl]-3-quinolinecarboxylic acid (0.0152 mol) in 50 mL water containing 0.06 mol sodium hydroxide is heated at 75°-80° C. for two hours. The solution is cooled to 5° C. and acidified with concentrated HCl. The precipitate is removed by filtration, washed with water and air-dried to give 6-difluoromethoxy-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-quinolinecarboxylic acid, mp 208°-209° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04647301 |
|---|
| Source dataset | uspto-grants-1987_03 |
|---|
| ORD ID | ord-6cb281cae16d449284b38c13624742bf |
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| Source note | uspto-grants-1987_03 |
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