Hydrochloric Acid → HCID 13730839, compound

HRID 1905596Notes

Reaction equation

HRID 1905596 reaction equation
[F:1][CH:2]([F:28])[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14](=O)[NH:15][C:16]([C:21](=[O:23])[NH2:22])([CH3:20])[CH:17]([CH3:19])[CH3:18])[C:8]([C:25]([OH:27])=[O:26])=[CH:7]2.O.Cl>>[F:1][CH:2]([F:28])[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([C:14]1[NH:22][C:21](=[O:23])[C:16]([CH:17]([CH3:19])[CH3:18])([CH3:20])[N:15]=1)[C:8]([C:25]([OH:27])=[O:26])=[CH:7]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 13474746HCID 13474746, compound

Product 1

HCID 13730839HCID 13730839, compound

Conditions

Temperature
5 °C

Procedure

A solution of 6-difluoromethoxy-2-[(1-carbamoyl-1,2-dimethylpropyl)-carbamoyl]-3-quinolinecarboxylic acid (0.0152 mol) in 50 mL water containing 0.06 mol sodium hydroxide is heated at 75°-80° C. for two hours. The solution is cooled to 5° C. and acidified with concentrated HCl. The precipitate is removed by filtration, washed with water and air-dried to give 6-difluoromethoxy-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-quinolinecarboxylic acid, mp 208°-209° C.

Workup

  1. customThe precipitate is removed by filtration
  2. washwashed with water
  3. customair-dried

Sources & evidence

ORD record
ord-6cb281cae16d449284b38c13624742bf
Source dataset
uspto-grants-1987_03
Patent number
US04647301

Reaction notes

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