Methanol → 6-((trans-4-aminocyclohexyl)amino)-N-4-pyridinyl-8-(4-pyrimidinylamino)imidazo[1,2-b]pyridazine-3-carboxamide

HRID 190563Notes

Reaction equation

HRID 190563 reaction equation
[CH3:35][N:36]1[CH2:37][CH2:38][CH2:39][C:40]1=[O:41].[CH3:42][OH:43].[CH:27]1([NH2:34])[CH2:28][CH2:29][CH:30]([NH2:33])[CH2:31][CH2:32]1.[Cl:1][c:2]1[cH:3][c:4]([NH:20][c:21]2[n:22][cH:23][n:24][cH:25][cH:26]2)[c:5]2[n:6]([n:7]1)[c:8]([C:11](=[O:12])[NH:13][c:14]1[cH:15][cH:16][n:17][cH:18][cH:19]1)[cH:9][n:10]2>>[c:2]1([NH:34][CH:27]2[CH2:28][CH2:29][CH:30]([NH2:33])[CH2:31][CH2:32]2)[cH:3][c:4]([NH:20][c:21]2[n:22][cH:23][n:24][cH:25][cH:26]2)[c:5]2[n:6]([n:7]1)[c:8]([C:11](=[O:12])[NH:13][c:14]1[cH:15][cH:16][n:17][cH:18][cH:19]1)[cH:9][n:10]2

Participants

5

Reactant 4

HCID 887MethanolHCID 13387N-methyl-2-pyrrolidoneHCID 183741,4-DiaminocyclohexaneHCID 596244986-chloro-N-(pyridin-4-yl)-8-(pyrimidin-4-ylamino)imidazo[1,2-b]pyridazine-3-carboxamide

Product 1

HCID 596243886-((trans-4-aminocyclohexyl)amino)-N-4-pyridinyl-8-(4-pyrimidinylamino)imidazo[1,2-b]pyridazine-3-carboxamide

Sources & evidence

ORD record
ord-3884794bb2724d30ab4aafab8f280c76
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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