HCID 136134531, compound → HCID 135782143, compound

HRID 1905633Notes

Reaction equation

HRID 1905633 reaction equation
[CH3:1][C:2]1[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[NH:21][C:20](=[O:28])[C:4]2([CH2:9][CH2:8][N:7](C(OCC3C=CC=CC=3)=O)[CH2:6][CH2:5]2)[N:3]=1>C(O)C.[Pd]>[CH3:1][C:2]1[C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[NH:21][C:20](=[O:28])[C:4]2([CH2:5][CH2:6][NH:7][CH2:8][CH2:9]2)[N:3]=1

Participants

4

Reactant 1

HCID 136134531HCID 136134531, compound

Product 1

HCID 135782143HCID 135782143, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

6.0 g (0.016 mole) of 5-methyl-1'-benzyloxycarbonyl-spiro-[1H-1,4-benzodiazepine-3,4'-piperidin]-2(3H)-one are hydrogenated in 250 ml of ethanol in the presence of 0.5 g of palladium-on-charcoal at 20° C. After the catalyst has been removed by filtration, the filtrate is concentrated and, after addition of diethyl ether, the residue crystallizes.

Workup

  1. customAfter the catalyst has been removed by filtration
  2. concentrationthe filtrate is concentrated
  3. additionafter addition of diethyl ether
  4. customthe residue crystallizes

Sources & evidence

ORD record
ord-742114cccd304b35927c20b4cd046fd5
Source dataset
uspto-grants-1987_03
Patent number
US04647560

Reaction notes

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