tert-Butanol → HCID 20215001, compound

HRID 1905636Notes

Reaction equation

HRID 1905636 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:8]1[C:13](=[O:14])[O:12][C:10](=O)[CH2:9]1)([O-:3])=[O:2].[NH2:18]/[C:19](/[CH3:25])=[CH:20]\[C:21]([O:23][CH3:24])=[O:22].C([OH:30])(C)(C)C>>[OH:30][C:9]12[CH2:10][O:12][C:13](=[O:14])[CH:8]1[CH:7]([C:6]1[CH:15]=[CH:16][CH:17]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[C:20]([C:21]([O:23][CH3:24])=[O:22])=[C:19]([CH3:25])[NH:18]2

Participants

4

Reactant 3

HCID 6386tert-ButanolHCID 643918Methyl 3-aminocrotonateHCID 54163824HCID 54163824, compound

Product 1

HCID 20215001HCID 20215001, compound

Conditions

Temperature
30 °C

Procedure

##STR6## 4 mmol of 3-(3-nitrobenzylidene)-4-oxo-butyrolactone (E/Z mixture) and 4.4 mmol of methyl 3-aminocrotonate are suspended in 5 g of tert.-butanol, and the suspension is stirred for 3 hours at 30° C. It is evaporated down at room temperature in a rotary evaporator, and the residue is crystallized with a small amount of methanol. M.p.: 147°-149° C. (from methanol):

Workup

  1. customIt is evaporated down at room temperature in a rotary evaporator
  2. customthe residue is crystallized with a small amount of methanol

Sources & evidence

ORD record
ord-abb949e888ac486990b40623257148aa
Source dataset
uspto-grants-1987_03
Patent number
US04647568

Reaction notes

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