反应详情

A stirred solution of α-cyano-β(4-methoxyphenyl)propionic acid (127.3 g) in DMF (280 ml) is heated to 150° C. for 5 hours. The reaction mixture is cooled, poured into a liter of water and extracted with ether. The ether extract is washed, dried over Na2SO4, filtered and the filtrate evaporated in vacuo yielding a liquid which upon distillation yields the decarboxylated product as a clear liquid, B.P. 115° C. (1 mm).

1. temperatureThe reaction mixture is cooled
2. extractionextracted with ether
3. extractionThe ether extract
4. washis washed
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customthe filtrate evaporated in vacuo
8. customyielding a liquid which
9. distillationupon distillation