Piperidine → HCID 13799024, compound

HRID 1905739Notes

Reaction equation

HRID 1905739 reaction equation
S(O)(=O)(=O)C.[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14]O)[CH2:12][C:11]2=[CH:16][CH:17]=1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>C1(C)C=CC=CC=1>[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[CH2:12][C:11]2=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 131714665HCID 131714665, compound

Product 1

HCID 13799024HCID 13799024, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 5-methoxy-1-hydroxymethylbenzocyclobutene mesylate (38 g) and piperidine (45 ml) in toluene (180 ml) is refluxed under nitrogen for about 12 hours. The reaction mixture is filtered and the filtrate is evaporated in vacuo leaving a liquid residue which is used without further purification in the next step.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated in vacuo
  3. customleaving a liquid residue which
  4. customis used without further purification in the next step

Sources & evidence

ORD record
ord-b603286d38a049fd8fdec0e91fe3f548
Source dataset
uspto-grants-1987_03
Patent number
US04647559

Reaction notes

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