Triethylamine → HCID 131714667, compound

HRID 1905742Notes

Reaction equation

HRID 1905742 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[Cl:6][CH2:7][CH2:8][CH2:9][O:10][C:11]12[CH:20]=[CH:19][CH:18]=[CH:17][CH:12]1[CH2:13][CH:14]2[CH2:15][OH:16].C(N(CC)CC)C>C(Cl)Cl>[S:2]([OH:4])(=[O:10])(=[O:3])[CH3:1].[Cl:6][CH2:7][CH2:8][CH2:9][O:10][C:11]12[CH:20]=[CH:19][CH:18]=[CH:17][CH:12]1[CH2:13][CH:14]2[CH2:15][OH:16]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 131714668HCID 131714668, compound

Product 1

HCID 131714667HCID 131714667, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methane sulfonylchloride (1.13 g) is added dropwise to a stirred solution of 3-(3-chloropropoxy)-1-hydroxymethylbenzocyclobutene (1.83 g) and triethylamine (1.58 ml) in methylene chloride (32 ml) at 5° C. under nitrogen. The reaction mixture is stirred at RT for about 2 hours, washed with water, saturated NaCl, dried over Na2SO4, filtered and evaporated in vacuo yielding the desired product as an oil.

Workup

  1. washwashed with water, saturated NaCl
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-022b9d7056374c108e707a5c50bb722e
Source dataset
uspto-grants-1987_03
Patent number
US04647559

Reaction notes

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