HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylamine → HCID 20213161, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylamine | HCID 1146 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | N,N-Dimethylpyrimidin-4-amine | HCID 579196 | — |
| Reactant | HCID 20213160 | HCID 20213160 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 20213161 | HCID 20213161 | — |
Reaction Steps
A solution of 3.1 g of 4,6-dichloro-5-hydroxy-2-phenylpyrimidine, 2.8 ml of trimethylamine, 1.6 ml of acetic anhydride and 0.1 g of 4-dimethylaminopyrimidine in 50 ml of toluene is stirred for 4 hours at 20°-25° C. The reaction solution is subsequently diluted with ethyl acetate, washed with water and dried. On concentration by evaporation, there crystallise 4.3 g of 5-acetoxy-4,6-dichloro-2-phenylpyrimidine, m.p. 145°-147° C. (compoud No. 36).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04648896 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-d1b5f11638ef4474a07254691bec3798 |
| Source note | uspto-grants-1987_03 |