Trimethylamine → HCID 20213161, compound

HRID 1905844Notes

Reaction equation

HRID 1905844 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[C:6]([Cl:9])[N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1.CN(C)C.[C:20](OC(=O)C)(=[O:22])[CH3:21].CN(C)C1C=CN=CN=1>C1(C)C=CC=CC=1.C(OCC)(=O)C>[C:20]([O:8][C:7]1[C:6]([Cl:9])=[N:5][C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:3][C:2]=1[Cl:1])(=[O:22])[CH3:21]

Participants

7

Reactant 4

HCID 1146TrimethylamineHCID 7918Acetic AnhydrideHCID 5791964-(Dimethylamino)pyrimidineHCID 20213160HCID 20213160, compound

Product 1

HCID 20213161HCID 20213161, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 3.1 g of 4,6-dichloro-5-hydroxy-2-phenylpyrimidine, 2.8 ml of trimethylamine, 1.6 ml of acetic anhydride and 0.1 g of 4-dimethylaminopyrimidine in 50 ml of toluene is stirred for 4 hours at 20°-25° C. The reaction solution is subsequently diluted with ethyl acetate, washed with water and dried. On concentration by evaporation, there crystallise 4.3 g of 5-acetoxy-4,6-dichloro-2-phenylpyrimidine, m.p. 145°-147° C. (compoud No. 36).

Workup

  1. washwashed with water
  2. customdried
  3. concentrationOn concentration
  4. customby evaporation, there
  5. customcrystallise 4.3 g of 5-acetoxy-4,6-dichloro-2-phenylpyrimidine, m.p. 145°-147° C. (compoud No. 36)

Sources & evidence

ORD record
ord-d1b5f11638ef4474a07254691bec3798
Source dataset
uspto-grants-1987_03
Patent number
US04648896

Reaction notes

Loading…