Hydrochloric Acid → HCID 178463602, compound

HRID 1905845Notes

Reaction equation

HRID 1905845 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[CH2:5]([NH:7][C:8]1N=C(NCC)N=[C:10](Cl)[N:9]=1)[CH3:6].[OH-].[Na+].Cl>O1CCOCC1.O>[CH2:5]([NH:7][C:8]1[N:9]=[CH:10][N:4]=[C:2]([SH:3])[N:1]=1)[CH3:6]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 5216SimazineHCID 14798Sodium HydroxideHCID 2723790Thiourea

Product 1

HCID 178463602HCID 178463602, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 1.5 g of thiourea and 4 g of 2,4-bis(ethylamino)-6-chloro-1,3,5-triazine in a mixture of 20 ml of dioxane and 20 ml of water is refluxed with stirring for 2 hours in 100 ml flask. After cooling, the mixture is mixed with 1.6 g of 50% sodium hydroxide and stirred for 10 minutes. The resulting mixture is neutralized with hydrochloric acid and extracted with ethyl acetate. The extract is concentrated under reduced pressure to give 4 g of 2,4-bis(ethylamino-6-mercapto-1,3,5-triazine. The product can be used for preparation of the objective compound without isolation.

Workup

  1. temperatureis refluxed
  2. temperatureAfter cooling
  3. stirringstirred for 10 minutes
  4. extractionextracted with ethyl acetate
  5. concentrationThe extract is concentrated under reduced pressure

Sources & evidence

ORD record
ord-ece3f5e15c1949ef980cc2538cacbfc1
Source dataset
uspto-grants-1987_03
Patent number
US04648898

Reaction notes

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