Methyl iodide → HCID 20213386, compound

HRID 1905868Notes

Reaction equation

HRID 1905868 reaction equation
[C:1]1([C:7]2([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:11][C:10](=[S:12])[NH:9][C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20](=O)([O-])[O-].[Na+].[Na+].IC>C(O)C>[C:14]1([C:7]2([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[NH:11][CH:10]([S:12][CH3:20])[NH:9][C:8]2=[O:13])[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 10340Sodium CarbonateHCID 8541504-Imidazolidinone, 5,5-diphenyl-2-thioxo-

Product 1

HCID 20213386HCID 20213386, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7.0 g of 5,5-diphenyl-2-thiohydantoin is dissolved in 50 ml of ethanol and 10 ml of 3N sodium carbonate added followed by 3 ml of iodomethane. The mixture is refluxed for 18 hours, then cooled and the solvent evaporated. The residual solid is recrystallized from ethanol to give 4.6 g (60%) of the title compound.

Workup

  1. temperatureThe mixture is refluxed for 18 hours
  2. temperaturecooled
  3. customthe solvent evaporated
  4. customThe residual solid is recrystallized from ethanol

Sources & evidence

ORD record
ord-f98febb39d2045f1bff5d76a9b09caa6
Source dataset
uspto-grants-1987_03
Patent number
US04649145

Reaction notes

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