反应详情

温度

100 °C

To a solution of 6-(3,4-dimethoxyphenyl)-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (2.0 g) in acetic acid (100 ml) was added N-chlorosuccinimide (0.97 g), and the mixture was stirred at 100° C. for 5 hours. After cooling, the reaction mixture was evaporated, and dissolved in chloroform, The solution was washed with aqueous sodium bicarbonate, and dried over magnesium sulfate. After removal of the solvent, resulting mass was crystallized from ethanol, to give 5-chloro-6-(3,4-dimethoxyphenyl)-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (1.79 g).

1. temperatureAfter cooling
2. customthe reaction mixture was evaporated
3. dissolutiondissolved in chloroform
4. washThe solution was washed with aqueous sodium bicarbonate
5. dry with materialdried over magnesium sulfate
6. customAfter removal of the solvent
7. customresulting mass
8. customwas crystallized from ethanol