反应详情

Thiourea (1.4 g) and ethyl 2-formyl-3-(3-pyridyl)butyrate (3.4 g) was added to a solution of sodium ethoxide (from 0.78 g sodium) in ethanol (45 ml). The mixture was heated under reflux for 7 hours and evaporated. The residue was taken up in water and extracted with chloroform at pH 13. The pH was adjusted to 7.0 and the mixture allowed to stand at 0° overnight. The solid was filtered off to give 5-[1-(3-pyridyl)ethyl]-2-thiouracil (1.83 g) m.p. 225°-228° (from 2-propanol).

1. temperatureThe mixture was heated
2. temperatureunder reflux for 7 hours
3. customevaporated
4. extractionextracted with chloroform at pH 13
5. filtrationThe solid was filtered off