HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178471870, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,6-Dichloro-5-fluoro-3-pyridinecarbonyl chloride | HCID 2733666 | — |
| Reactant | Ethyl 3-(cyclopropylamino)prop-2-enoate | HCID 53428729 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 178471870 | HCID 178471870 | — |
Reaction Steps
In dry dioxane, 2,6-dichloro-5-fluoronicotinoyl chloride, prepared in Reference Example 10-(2), was allowed to react with ethyl β-cyclopropylaminoacrylate in the presence of triethylamine to give ethyl 2-(2,6-dichloro-5-fluoronicotinoyl)-3-cyclopropylaminoacrylate, m.p. 129°-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04649144 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-4183ba61e69d487eb66d6c348c6ac87b |
| Source note | uspto-grants-1987_03 |