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HRID1905923

反应详情

EQUATION

反应方程式

HRID 1905923 的结构方程式

REACTANTS

反应物

3
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：O=C(Cl)c1cc(F)c(Cl)nc1Cl
HCID2733666

2,6-Dichloro-5-fluoropyridine-3-carbonyl chloride

C6HCl3FNO

结构：CCOC(=O)C=CNC1CC1
HCID53428729

Ethyl 3-(cyclopropylamino)prop-2-enoate

C8H13NO2

PRODUCTS

生成物

1
结构：CCOC(=O)C(=CNC1CC1)C(=O)c1cc(F)c(Cl)nc1Cl
HCID178471870

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

In dry dioxane, 2,6-dichloro-5-fluoronicotinoyl chloride, prepared in Reference Example 10-(2), was allowed to react with ethyl β-cyclopropylaminoacrylate in the presence of triethylamine to give ethyl 2-(2,6-dichloro-5-fluoronicotinoyl)-3-cyclopropylaminoacrylate, m.p. 129°-130° C.