Triethylamine → HCID 178471870, compound

HRID 1905923Notes

Reaction equation

HRID 1905923 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]([Cl:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH:13]1([NH:16][CH:17]=[CH:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:15][CH2:14]1.C(N(CC)CC)C>O1CCOCC1>[Cl:1][C:2]1[N:10]=[C:9]([Cl:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([C:18](=[CH:17][NH:16][CH:13]1[CH2:14][CH2:15]1)[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:5]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27336662,6-Dichloro-5-fluoro-3-pyridinecarbonyl chlorideHCID 53428729Ethyl 3-(cyclopropylamino)prop-2-enoate

Product 1

HCID 178471870HCID 178471870, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In dry dioxane, 2,6-dichloro-5-fluoronicotinoyl chloride, prepared in Reference Example 10-(2), was allowed to react with ethyl β-cyclopropylaminoacrylate in the presence of triethylamine to give ethyl 2-(2,6-dichloro-5-fluoronicotinoyl)-3-cyclopropylaminoacrylate, m.p. 129°-130° C.

Sources & evidence

ORD record
ord-4183ba61e69d487eb66d6c348c6ac87b
Source dataset
uspto-grants-1987_03
Patent number
US04649144

Reaction notes

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