Methanimidic acid, N-cyano-, ethyl ester → HCID 178432550, compound

HRID 1905942Notes

Reaction equation

HRID 1905942 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=2)[N:6]=1.[C:14]([N:16]=[CH:17]OCC)#[N:15]>C(O)C>[C:14]([NH:16][CH:17]=[N:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[N:6]=[C:2]([CH3:1])[NH:3][CH:4]=2)=[CH:8][CH:9]=1)#[N:15]

Participants

4

Reactant 2

HCID 9920370Methanimidic acid, N-cyano-, ethyl esterHCID 178432541HCID 178432541, compound

Product 1

HCID 178432550HCID 178432550, compoundYield 77.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-methyl-4-(4-amino-phenyl)-1H-imidazole (15 g) and ethyl N-cyanoformimidate (9.35 g) in ethanol (150 ml) was stirred at room temperature overnight. The product which crystallized out was collected by filtration, washed with cold ethanol and dried to give 15.2 g of the title compound.

Workup

  1. customThe product which crystallized out
  2. filtrationwas collected by filtration
  3. washwashed with cold ethanol
  4. customdried

Sources & evidence

ORD record
ord-65ce84783cb14901bddb68c68cc2adbc
Source dataset
uspto-grants-1987_03
Patent number
US04649150

Reaction notes

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