1-Methylpiperazine → HCID 13787496, compound

HRID 1905945Notes

Reaction equation

HRID 1905945 reaction equation
[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([N:14]=[C:15]=[S:16])[CH:11]=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>CCOCC>[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([NH:14][C:15]([N:21]3[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]3)=[S:16])[CH:11]=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 13787495HCID 13787495, compound

Product 1

HCID 13787496HCID 13787496, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

70 g (0.28 mole) of 2-tert.-butyl-6-isothiocyano-benzthiazole are dissolved in 1200 ml of ether and 33 g (0.33 mole) of 4-methylpiperazine are added dropwise, while stirring. The mixture is stirred for 1 hour, filtered and washed first with ether, then with petroleum ether. 2-tert.-butyl-6-[(4-methylpiperazin-1-yl)-thiocarbonylamino]-benzthiazole having a melting point of 176°-177° is obtained: ##STR13##

Workup

  1. stirringThe mixture is stirred for 1 hour
  2. filtrationfiltered
  3. washwashed first with ether

Sources & evidence

ORD record
ord-4c4e55480ed84d87aa7c3cae36d7871d
Source dataset
uspto-grants-1987_03
Patent number
US04649149

Reaction notes

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