HCID 13588837, compound → HCID 54395479, compound

HRID 1905959Notes

Reaction equation

HRID 1905959 reaction equation
[CH2:1]([C:5]1[S:9][C:8]([CH:10]([CH2:14][C:15]([OH:17])=[O:16])[C:11]([OH:13])=O)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3]>C(Cl)(=O)C>[CH2:1]([C:5]1[S:9][C:8]([CH:10]2[CH2:14][C:15](=[O:16])[O:17][C:11]2=[O:13])=[CH:7][CH:6]=1)[CH:2]([CH3:3])[CH3:4]

Participants

3

Reactant 1

HCID 13588837HCID 13588837, compound

Product 1

HCID 54395479HCID 54395479, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 6367Acetyl chlorideSolvent

Procedure

10 g of (5-isobutyl-2-thienyl)succinic acid was added to 40 cc of acetyl chloride and the mixture was refluxed for 1 hour 30 minutes. The excess acetyl chloride was evaporated under reduced pressure. Distillation of the residue provided 7.9 g (yield=85%) of (5-isobutyl-2-thienyl)succinic anhydride.

Workup

  1. temperaturethe mixture was refluxed for 1 hour 30 minutes
  2. customThe excess acetyl chloride was evaporated under reduced pressure
  3. distillationDistillation of the residue

Sources & evidence

ORD record
ord-d99d16d11ac04b1e84b12f51b7d862ad
Source dataset
uspto-grants-1987_03
Patent number
US04649153

Reaction notes

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