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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1905983Generated: October 26, 2026

Chloroacetic Acid → 2-[2-(2,4-Difluorophenyl)ethoxy]acetic acid

https://huagongshe.com/reaction/1905983

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChloroacetic AcidHCID 300—
Reactant2-(2,4-Difluorophenyl)ethanolHCID 53403461—
Product2-[2-(2,4-Difluorophenyl)ethoxy]acetic acidHCID 2021372854.4%

Reaction Conditions

Temperature120 °C

Reaction Steps

3.63 g of 2,4-difluorophenethyl alcohol were reacted with 2.17 g of chloroacetic acid in a manner analogous to that described in Example 1(a), except that the reaction mixture was heated at 120° C. for 1 hour, to give 2.7 g (54%) of 2-(2,4-difluorophenyl)ethoxyacetic acid in the form of an oil which was homogeneous according to chromatography.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04649160
Source datasetuspto-grants-1987_03
ORD IDord-1af4a45575fc4ec6904e5fe919aa2779
Source noteuspto-grants-1987_03