Hydroxylamine → HCID 136332181, compound

HRID 1906015Notes

Reaction equation

HRID 1906015 reaction equation
[CH:1]([C:3]1[N:4]=[C:5]([NH:14][CH3:15])[S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)=O.[NH2:16][OH:17]>CO>[OH:17][N:16]=[CH:1][C:3]1[N:4]=[C:5]([NH:14][CH3:15])[S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 20144978HCID 20144978, compound

Product 1

HCID 136332181HCID 136332181, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-formyl-2-methylamino-5-(4-pyridyl)-thiazole (0.9 g) in methanol (15 ml) was added to a 1N-methanolic hydroxylamine solution (5.8 ml) at ambient temperature with stirring, which was continued under the same condition for 2 hours. The precipitate was collected by filtration and recrystallized from an aqueous tetrahydrofuran to afford 4-hydroxyiminomethyl-2-methylamino-5-(4-pyridyl)thiazole (1.02 g).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customrecrystallized from an aqueous tetrahydrofuran

Sources & evidence

ORD record
ord-da78f2e692534d7fb9ad244b910d118f
Source dataset
uspto-grants-1987_03
Patent number
US04649146

Reaction notes

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