反应详情

The compound prepared in Example 40 (10.5 g, 0.037 mol) is suspended in 150 mL absolute methanol and 4.0 g sodium methoxide is added. After stirring for 72 hours at room temperature the mixture is poured onto ice containing acetic acid to maintain the pH at 3-4. A white solid forms and is filtered yielding 9.8 g (84%) of the title compound with mp 134°-137° C.

1. additionis poured onto ice
2. temperatureto maintain the pH at 3-4
3. filtrationA white solid forms and is filtered