HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Methyl 6-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-furo[2,3-b]pyridine-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 2-isopropyl-2-methyl-5H-furo[2,3-b]imidazo[2',1':5,1]pyrrolo[3,4-e]pyridine-3(2H), 5-dione | HCID 13849610 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 6-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-furo[2,3-b]pyridine-5-carboxylate | HCID 13752471 | 84% |
Reaction Steps
The compound prepared in Example 40 (10.5 g, 0.037 mol) is suspended in 150 mL absolute methanol and 4.0 g sodium methoxide is added. After stirring for 72 hours at room temperature the mixture is poured onto ice containing acetic acid to maintain the pH at 3-4. A white solid forms and is filtered yielding 9.8 g (84%) of the title compound with mp 134°-137° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04650514 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-af5318df6bea46bc844c247836c934c4 |
| Source note | uspto-grants-1987_03 |