反应详情

2.3 Grams (3.25 m moles) of Z-D-Ala-Phe-Arg(NO2)-CHA was suspended in a mixed solvent of 113 ml of MeOH, 35 ml of H2O and 2.1 ml of 1N-HCl. To this suspension was added 1 g of palladium black and reduced by hydrogenation at 30° C. for 4 hours. After the hydrogenation was completed the catalyst was removed by filtration, further the solvent was removed by evaporation under reduced pressure. The residue thus obtained was purified by using a gel filtration column of TOYOPEARL HW 40F with MeOH as the developing solvent to obtain 1.5 g (78.2%) of H-D-Ala-Phe-Arg-CHA.2HCl.

1. customwas removed by filtration
2. customfurther the solvent was removed by evaporation under reduced pressure
3. customThe residue thus obtained
4. customwas purified
5. filtrationa gel filtration column of TOYOPEARL HW 40F with MeOH as the developing solvent