p-Toluenesulfonic acid → HCID 13517151, compound

HRID 1906144Notes

Reaction equation

HRID 1906144 reaction equation
[NH:1]([C:17]([O:19][C:20]([C:23]1[CH:32]=[C:29]([O:30][CH3:31])[CH:28]=[C:25]([O:26][CH3:27])[CH:24]=1)([CH3:22])[CH3:21])=[O:18])[C@H:2]([C:14](O)=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:33][C@H:34]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[CH:35]([CH3:37])[CH3:36].CC1C=CC(S(O)(=O)=O)=CC=1>>[NH:1]([C:17]([O:19][C:20]([C:23]1[CH:24]=[C:25]([O:26][CH3:27])[CH:28]=[C:29]([O:30][CH3:31])[CH:32]=1)([CH3:22])[CH3:21])=[O:18])[C@H:2]([C:14]([NH:33][C@H:34]([C:38]([O:40][C:41]([CH3:42])([CH3:44])[CH3:43])=[O:39])[CH:35]([CH3:37])[CH3:36])=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 114626tert-Butyl L-valinateHCID 13517149HCID 13517149, compound

Product 1

HCID 13517151HCID 13517151, compound

Procedure

The peptide coupling is carried out by the PPA method as described for (a). Batch: 13.4 g (30 mmol) of Ddz-Asp(OBzl)-OH and 10.36 g (30 mmol) of H-Val-OBut.TsOH.

Sources & evidence

ORD record
ord-d200fa13141249b4b89a3682dbda7064
Source dataset
uspto-grants-1987_03
Patent number
US04650788

Reaction notes

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