HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2(1H)-pyrimidinone → HCID 12791250, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2(1H)-pyrimidinone | HCID 101494 | — |
| Reactant | 2-Bromo-1-(thiophen-3-yl)ethan-1-one | HCID 2776379 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 12791250 | HCID 12791250 | 39.7% |
Reaction Steps
A mixture of 5-bromopyrimidin-2-one (700 mg) and 3-bromoacetylthiophene (1.025 g) in triethylamine (0.84 ml) and ethanol (25 ml) was stirred at room temperature. After 1 h. the mixture was cooled to 3° C. and the precipitate collected. The dried solid was crystallised from ethanol to give the title pyrimidinone (475 mg), m.p. 180°-182° C. (dec), λmax (EtOH) 250.5 nm (ε 14,930), 334.5 nm (ε 3,260).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04650800 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-4c50fc296bf34e9584b22c8bd2ce4206 |
| Source note | uspto-grants-1987_03 |