Hydrochloric Acid → HCID 13823146, compound

HRID 1906164Notes

Reaction equation

HRID 1906164 reaction equation
[CH3:1][NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[N:7]=1.Br[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].Cl>O>[CH3:1][NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[CH2:9][N:10]([CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:11][CH2:12][CH:13]=2)[N:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 80571-BromopentaneHCID 1382315056541-06-1

Product 1

HCID 13823146HCID 13823146, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The procedure of Example 1 was repeated, using the N-methyl-4-(3-pyridinyl)-2-thiazolamine prepared in Example 14 and an excess of 1-bromopentane as the reactants. The title compound was purified by column chromatography (53% yield) and converted to its HCl salt by the procedure of Example 2. The salt obtained (mp 168°-172° C.) contained 1.5 molecules of HCl and one molecule of water.

Workup

  1. customThe title compound was purified by column chromatography (53% yield)
  2. customThe salt obtained (mp 168°-172° C.)

Sources & evidence

ORD record
ord-78e34d5015b943fe8da8aac56fd7160e
Source dataset
uspto-grants-1987_03
Patent number
US04650805

Reaction notes

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