Hydrochloric Acid → HCID 20212868, compound

An ice cold solution of sodium nitrite (1.088 g) in water (6 ml) was added to a stirred solution of 2-(4-aminophenyl)-N,N-dimethylacetamide (2.67 g) in concentrated hydrochloric acid (10 ml) at -5° C. After stirring the yellow solid for 15 min, it was added to a stirred solution of stannous chloride (16.88 g) in concentrated hydrochloric acid (10 ml) at -10° C. When the addition was complete, the mixture was stirred at room temperature for a further 30 min and poured into ethanol (100 ml). The mixture was evaporated to dryness under reduced pressure, basified using 2N sodium hydroxide (350 ml) and extracted with ethyl acetate (3×200 ml). Evaporation of the dried (Na2SO4) solvent gave a pale yellow gum which was dried under high vacuum. This was dissolved in ethyl acetate (50 ml) and ethereal hydrogen chloride was added until no more solid deposited. Collection of the solid by filtration and washing with ether gave the title compound as a white powder (1.45 g) which was 82.6% pure and was used in the next stage without further purification.

1. additionWhen the addition
2. stirringthe mixture was stirred at room temperature for a further 30 min
3. customThe mixture was evaporated to dryness under reduced pressure
4. extractionextracted with ethyl acetate (3×200 ml)
5. customEvaporation of the
6. dry with materialdried (Na2SO4) solvent
7. customgave a pale yellow gum which
8. customwas dried under high vacuum
9. dissolutionThis was dissolved in ethyl acetate (50 ml)
10. additionethereal hydrogen chloride was added until no more solid
11. customCollection of the solid
12. filtrationby filtration
13. washwashing with ether

ORD record

ord-4ca5909f67c1425d91846417193d4e56

Source dataset

uspto-grants-1987_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04650810